‘Sure, that is definitely about correct. I seek out a physical knowledge of Organic units within a base-up way. I do think you can distinguish 3 strains of study in my group at the moment. The primary fears chromosome structure: How will you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? We've got created visualisation tactics that allow for us to study how, by way of example, SMC proteins loop DNA (movie on Youtube) so that you can Develop up chromosomes.

Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules

The next content are merged in Scholar. Their put together citations are counted just for the very first write-up.

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on single molecules and metallic clusters

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first at any time examine of the dynamics DNA supercoils and the invention of supercoil hopping

The coiled-coil on the human Rad50 DNA restore protein includes distinct segments of enhanced overall flexibility

We condition microbes into sorts that deviate from their purely natural phenotype. Specially, I'll present our ability to condition Stay E. coli micro organism into novel designs like rectangles, squares, triangles and circles.

Dynamic ParB–DNA interactions initiate and retain a partition condensate for bacterial chromosome segregation

The rotors harness Power from the nanoscale drinking water and ion flow that is created by a static chemical or electrochemical prospective cees dekker gradient inside the nanopore, that are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological problems, suggesting approaches to developing Strength-transducing motors at nanoscale interfaces.

Bulk-surface coupling identifies the mechanistic connection amongst Min-protein styles in vivo As well as in vitro

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Nanoscientist Cees Dekker is undoubtedly an amiable and flamboyant male who appears A lot younger than the sixty two decades he essentially is – stylish glasses, psychedelic shirt, engaging smile – although not one particular to waste time. He takes his time, but not more than needed.

2008, initial observation of protein-coated DNA translocation via nanopores; settled the origin in the electrophoretic power on DNA in nanopores; identified a substantial velocity improve of microtubules in electric fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid

2004, discovery of latest physics in translocation of DNA by means of nanopores; first experimental analyze of ions conduction in nanofluidic channels; 1st electrochemistry with person one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; first electrical docking of microtubules on kinesin-coated nanostructures; initially biophysics characterization in the mechanical properties of double-stranded RNA; and initially single-molecule analyze of DNA translocation by a restriction-modification enzyme.